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Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1 (CTHRC1) Are Strongly Associated with eGFR and

Yeldar Baiken1,2,3, Zhannur Markhametova4, Assem Ashimova1,2

  • 1School of Engineering and Digital Sciences, Nazarbayev University, Astana 010000, Kazakhstan.

Medicina (Kaunas, Lithuania)
|April 28, 2023
PubMed

Insights

Collagen triple helix repeat containing 1 (CTHRC1) shows promise as a novel blood biomarker for chronic kidney disease (CKD). Elevated plasma CTHRC1 levels significantly differentiate CKD patients from healthy individuals.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Clinical Chemistry

Background:

  • Chronic kidney disease (CKD) presents complex pathophysiology with diverse etiologies.
  • Key indicators of CKD include elevated plasma creatinine, proteinuria, albuminuria, and reduced estimated glomerular filtration rate (eGFR).
  • Existing biomarkers for CKD progression are limited, necessitating the search for novel diagnostic tools.

Purpose of the Study:

  • To investigate the potential of collagen triple helix repeat containing 1 (CTHRC1) as a blood biomarker for CKD.
  • To evaluate the correlation of CTHRC1 levels with established clinical markers of kidney function.
  • To determine if plasma CTHRC1 levels can differentiate between CKD patients and healthy controls.

Main Methods:

  • Study included 26 CKD patients and 18 healthy controls.
  • Collected clinical characteristics, complete blood counts, and biochemical analyses.
  • Utilized human ELISA kits to quantify plasma CTHRC1 levels and other potential biomarkers.

Main Results:

  • Plasma CTHRC1 levels showed a significant correlation with 24-hour urine total protein, creatinine, urea, and uric acid.
  • A highly significant difference (p ≤ 0.0001) in CTHRC1 levels was observed between the CKD group and the control group.
  • CTHRC1 levels were found to be significantly elevated in CKD patients compared to healthy individuals.

Conclusions:

  • Plasma CTHRC1 levels can effectively distinguish individuals with CKD from healthy subjects.
  • CTHRC1 emerges as a potential diagnostic biomarker for CKD.
  • Further research with larger, diverse patient cohorts is warranted to validate these findings and explore clinical utility.

Keywords:
CKDCTHRC1chronic kidney diseaseglomerulonephritiskidney disease

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