Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Regenerative Medicine

Background:

• Three-dimensional (3D) bioprinting is a key technology for creating complex tissue substitutes.
• Decellularized extracellular matrix (dECM) is a natural biomaterial rich in bioactive factors crucial for tissue regeneration.
• dECM-derived bioinks offer advantages over other bioinks due to their inherent signaling capabilities.

Purpose of the Study:

• To review the current advancements and future perspectives of decellularized extracellular matrix (dECM)-based bioinks in 3D bioprinting.
• To discuss the application of dECM bioinks for constructing tissue substitutes in tissue engineering.

Main Methods:

• Review of existing literature on dECM bioinks, 3D bioprinting techniques, and decellularization processes.
• Analysis of the properties and benefits of dECM components in modulating cellular functions and tissue remodeling.

Main Results:

• dECM bioinks possess complex structures and bioactive factors that support tissue regeneration and remodeling.
• dECM-based bioinks can regulate cellular functions and modulate the tissue regeneration process effectively.
• Various bioprinting techniques and decellularization methods are crucial for dECM bioink development.

Conclusions:

• dECM-based bioinks represent a promising frontier in 3D bioprinting for tissue engineering.
• Further research into dECM bioinks, bioprinting strategies, and decellularization techniques will advance tissue regeneration therapies.