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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Current Understanding of Flavonoids in Cancer Therapy and Prevention
Mohd Farhan1, Asim Rizvi2, Mohammad Aatif3
1Department of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al Ahsa 31982, Saudi Arabia.
Abstract:
Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development and progression. Recently, natural bioactive chemicals known as polyphenols found in plants were shown to have anticancer capabilities, destroying altered or malignant cells without harming normal cells. Flavonoids have demonstrated antioxidant, antiviral, anticancer, and anti-inflammatory effects. Flavonoid type, bioavailability, and possible method of action determine these biological actions. These low-cost pharmaceutical components have significant biological activities and are beneficial for several chronic disorders, including cancer. Recent research has focused primarily on isolating, synthesizing, and studying the effects of flavonoids on human health. Here we have attempted to summarize our current knowledge of flavonoids, focusing on their mode of action to better understand their effects on cancer.
Insights
Flavonoids, natural plant compounds, show promising anticancer effects by targeting malignant cells. This review summarizes their mechanisms of action against cancer, highlighting their potential as therapeutic agents.
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
Background:
- Cancer is a leading global cause of mortality with diverse risk factors including genetics, inflammation, and environmental exposures.
- Polyphenols, particularly flavonoids, are plant-derived bioactive compounds exhibiting significant anticancer properties.
- Flavonoids demonstrate antioxidant, anti-inflammatory, antiviral, and anticancer activities, with effects dependent on their type and bioavailability.
Purpose of the Study:
- To review the current understanding of flavonoids and their mechanisms of action in cancer.
- To explore the potential of flavonoids as therapeutic agents for cancer treatment.
Main Methods:
- Literature review of recent research on flavonoids and cancer.
- Analysis of studies focusing on the mode of action of flavonoids against cancer cells.
Main Results:
- Flavonoids selectively destroy cancer cells while sparing normal cells.
- The biological actions of flavonoids are influenced by their specific type, bioavailability, and mechanism of action.
- Flavonoids represent low-cost pharmaceutical components with substantial biological activities beneficial for chronic diseases like cancer.
Conclusions:
- Flavonoids possess significant anticancer potential through various mechanisms.
- Further research into flavonoid mechanisms can enhance their application in cancer therapy.
- Flavonoids are valuable natural compounds for managing cancer and other chronic health conditions.
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