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Andrei Cătălin Oprescu1, Cristina Grosu2, Walther Bild1

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Summary

Metabolic syndrome (MetS) is linked to cognitive decline in diabetic patients. Cognitive function, assessed by MMSE and MoCA, correlated with metabolic factors like insulin resistance and leptin levels.

Keywords:
Alzheimer’s diseaseinsulin resistanceleptinobesitytype 2 diabetes

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Area of Science:

  • Endocrinology
  • Neurology
  • Metabolic Diseases

Background:

  • Metabolic syndrome (MetS), characterized by diabetes and obesity, has systemic effects with poorly understood long-term consequences.
  • Cognitive disorders are increasingly recognized as a complication in patients with metabolic imbalances.

Purpose of the Study:

  • To investigate the association between metabolic imbalances, insulin resistance, leptin levels, and cognitive disorders in diabetic patients.
  • To evaluate the potential protective role of T2D and dyslipidemia medications against cognitive decline.

Main Methods:

  • The study included 148 diabetic patients.
  • Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).
  • Serum leptin and insulin were measured via ELISA; insulin resistance was calculated using HOMA-IR.

Main Results:

  • MMSE and MoCA scores showed associations with anthropometric parameters.
  • MoCA scores were significantly correlated with glycemic control and leptin levels.
  • A relationship was observed between metabolic syndrome components and cognitive decline in this cohort.

Conclusions:

  • Cognitive function in diabetic patients is associated with metabolic parameters and leptin levels.
  • Further research is required to elucidate the precise relationship between MetS components and cognitive decline.
  • Identifying therapeutic targets for cognitive impairment in metabolic syndrome is a critical future direction.