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Related Experiment Video

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Handgrip Strength Test and Bioelectrical Impedance Analysis in SARS-CoV-2 Patients Admitted to Sub-Intensive Unit.

Sonia Zotti1, Isabella Luci1, Panaiotis Finamore2

  • 1Department of Medicine and Surgery, Internship Program in Geriatrics, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21-00128 Roma, Italy.

Nutrients
|April 28, 2023
PubMed
Summary

Malnutrition screening tools like MNA-sf are not reliable predictors of mortality in hospitalized COVID-19 patients. However, hand-grip strength and phase angle may predict outcomes in younger and older patients, respectively.

Keywords:
Mini-Nutritional AssessmentSARS-CoV-2bioelectrical impedance analysishand-grip strengthin-hospital mortalitynutrition

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Area of Science:

  • Critical Care Medicine
  • Nutritional Science
  • Geriatrics

Background:

  • Hospitalized patients with SARS-CoV-2 pneumonia and respiratory failure face high risks of malnutrition and mortality.
  • Early identification of patients at risk is crucial for timely intervention.

Purpose of the Study:

  • To evaluate the predictive value of the Mini-Nutritional Assessment short form (MNA-sf), hand-grip strength (HGS), and bioelectrical impedance analysis (BIA) for in-hospital mortality or endotracheal intubation in COVID-19 patients.
  • To assess these predictors across different age groups (<70 and 70+ years).

Main Methods:

  • A cohort of 101 hospitalized patients with COVID-19 pneumonia was studied in a sub-intensive care unit.
  • MNA-sf, HGS, and BIA-derived parameters (skeletal mass index, phase angle) were assessed.
  • Area under the receiver operating characteristic curves (AUC) were computed to determine discriminative capacity, stratified by age.

Main Results:

  • MNA-sf alone or combined with HGS/BIA did not reliably predict mortality or intubation.
  • In younger patients (<70 years), HGS demonstrated predictive value (AUC: 0.77).
  • In older patients (70+ years), phase angle was the best predictor (AUC: 0.72), while MNA-sf with HGS showed an AUC of 0.66.

Conclusions:

  • MNA-sf is not a useful tool for predicting outcomes in COVID-19 pneumonia patients.
  • HGS and phase angle show potential as prognostic indicators for younger and older COVID-19 patients, respectively.