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Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
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Interplay between Phytochemicals and the Colonic Microbiota.

Chohee Kwon1, Meran Keshawa Ediriweera2, Somi Kim Cho1,3

  • 1Department of Environmental Biotechnology, Graduate School of Industry, Jeju National University, Jeju 63243, Republic of Korea.

Nutrients
|April 28, 2023
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Summary

Phytochemicals from food enhance health by interacting with gut microbiota. This review explores how these interactions and microbial metabolites impact human diseases and therapeutic potential.

Keywords:
colonic microbial metabolitesdiseasesdiversitygut microbiotaphytochemicalspolyphenols

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Area of Science:

  • Nutritional Science
  • Microbiology
  • Pharmacology

Background:

  • Phytochemicals, natural plant compounds, offer health benefits through absorption and gut microbiota modulation.
  • The gut microbiota and phytochemicals engage in a symbiotic relationship, influencing each other's composition and host health.
  • Understanding this interplay is crucial for leveraging phytochemicals' therapeutic potential.

Purpose of the Study:

  • To review the complex interactions between phytochemicals and the gut microbiota.
  • To explore the impact of these interactions on human diseases.
  • To highlight the therapeutic roles of microbial metabolites derived from phytochemicals.

Main Methods:

  • Literature review synthesizing current research on phytochemical-microbiota interactions.
  • Analysis of the role of gut microbial metabolites (e.g., SCFAs, amino acid derivatives, vitamins) in disease.
  • Examination of phytochemical metabolites produced by gut microbiota and their therapeutic effects.

Main Results:

  • Phytochemicals modulate gut microbiota composition and diversity, promoting beneficial bacteria.
  • Gut microbiota enzymes transform phytochemicals into bioactive metabolites with antioxidant, anti-inflammatory, and anticancer properties.
  • Phytochemicals and their metabolites influence host health via signaling pathways and production of beneficial substances.

Conclusions:

  • Phytochemical-gut microbiota interactions are key to health and disease management.
  • Targeting these interactions offers novel therapeutic strategies for various human diseases.
  • Further controlled human studies are essential to validate these findings and optimize interventions.