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Updated: Aug 1, 2025

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

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Maternal Serum Vitamin B12 during Pregnancy and Offspring Autism Spectrum Disorder

Andre Sourander1,2, Sanju Silwal1, Heljä-Marja Surcel3,4

  • 1Research Centre for Child Psychiatry, INVEST Flagship, University of Turku, 20014 Turku, Finland.

Nutrients
|April 28, 2023
PubMed

This study examined the association between maternal serum vitamin B12 levels during early pregnancy and offspring autism spectrum disorders (ASD) and subtypes. Based on a Finnish national birth cohort, case offspring (n = 1558) born in 1987-2007 and diagnosed with ASD by 2015 were matched with one control on date of birth, sex and place of birth. Maternal vitamin B12 levels were measured during first and early second trimesters of pregnancy. High maternal vitamin B12 levels (≥81th percentile) was associated with increased risk for offspring childhood autism, adjusted odds ratio, 1.59, 95% confidence interval 1.06-2.41 (p = 0.026). No significant associations were observed between maternal vitamin B12 levels and offspring Asperger's or pervasive developmental disorder/NOS.

Keywords:
ASDautism spectrum disordermaternalmaternal vitamin B12prenatal

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