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Related Experiment Videos

Deformational strain energy and erythrocyte shape.

D E McMillan, T P Mitchell, N G Utterback

    Journal of Biomechanics
    |January 1, 1986
    PubMed
    Summary

    Erythrocyte deformation studies often assume a discocyte shape has no strain energy. This research explores erythrocyte strain energy, finding it varies with unstressed curvature, challenging the discocyte unstressed model.

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    Area of Science:

    • Biophysics
    • Cellular mechanics

    Background:

    • Erythrocyte deformation analyses commonly assume the discocytic shape is unstressed, lacking strain energy.
    • This assumption relies on micropipette experiments and theoretical discrepancies in curvature rigidity.

    Purpose of the Study:

    • To investigate the dependence of erythrocyte strain energy on unstressed surface curvature and elastic moduli.
    • To evaluate an alternative model for erythrocyte deformation and its implications for cell shape.

    Main Methods:

    • Utilized polynomial descriptions (Evans and Fung) and strain energy expressions (Zarda et al.).
    • Varied unstressed membrane curvature from flatness to supra-spherical values.
    • Calculated strain energy using specified curvature and extensional elastic moduli.

    Main Results:

    • Erythrocyte strain energy decreases with increasing unstressed curvature, reaching two-thirds of the sphered cell value.
    • A cup-shaped erythrocyte's strain energy is higher than a discocyte's at sphered unstressed curvature but lower near flatness.
    • Curvature strain energy concentrates in the dimple, while extensional strain energy concentrates at the equator.

    Conclusions:

    • The proposed model explains cup-shaped erythrocyte formation but suggests high resistance to curvature deformation.
    • Both the unstressed discocyte and the presented model warrant consideration for analyzing erythrocyte deformation and adhesion.

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