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Epigenetic Targets and Their Inhibitors in Thyroid Cancer Treatment

Ke Zhang1, Junyao Wang1, Ziyan He1

  • 1Department of Nuclear Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai 200233, China.

Pharmaceuticals (Basel, Switzerland)
|April 28, 2023
PubMed

Insights

Epigenetic modifications offer promising new therapeutic targets for thyroid cancer, addressing challenges posed by drug resistance to current treatments. Further clinical trials are essential to explore these novel epigenetic agents.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Biologically targeted therapies have advanced thyroid cancer treatment but face drug resistance.
  • Exploring novel therapeutic targets is crucial for overcoming treatment limitations.

Purpose of the Study:

  • To review epigenetic modifications in thyroid cancer.
  • To update on epigenetic therapeutic agents for thyroid cancer treatment.

Main Methods:

  • Comprehensive literature review of epigenetic mechanisms in thyroid cancer.
  • Analysis of current epigenetic therapeutic agents and their targets.

Main Results:

  • Key epigenetic modifications in thyroid cancer include DNA methylation, histone modifications, non-coding RNAs, chromatin remodeling, and RNA alterations.
  • Epigenetic agents such as DNMT inhibitors, HDAC inhibitors, BRD4 inhibitors, KDM1A inhibitors, and EZH2 inhibitors are discussed.

Conclusions:

  • Epigenetics presents a promising therapeutic avenue for thyroid cancer.
  • Further clinical investigations are warranted to validate the efficacy of epigenetic therapies.
Keywords:
epigeneticsinhibitortargetthyroid cancer

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