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Streptococcus parasuis, an Emerging Zoonotic Pathogen, Possesses the Capacity to Induce Cerebral Inflammatory

Kexin Qi1, Xueli Yi2, Mingliu Wang3

  • 1State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

Pathogens (Basel, Switzerland)
|April 28, 2023
PubMed

Insights

Streptococcus parasuis clinical strains can infect the central nervous system, causing neurological symptoms and cerebral inflammation. This study investigates their pathogenic potential and brain inflammatory mechanisms.

Area of Science:

  • Microbiology
  • Immunology
  • Neurology

Background:

  • Streptococcus parasuis is an emerging pathogen causing peritonitis, pneumonia, and arthritis.
  • Clinical S. parasuis strains have demonstrated the ability to enter the central nervous system (CNS).
  • Understanding the pathogenesis and CNS inflammatory mechanisms of S. parasuis is crucial for developing treatments.

Purpose of the Study:

  • To investigate the neurological symptoms and cerebral inflammation induced by S. parasuis clinical strains NN1 and BS26 in mice.
  • To analyze the histopathological changes and cerebral immune responses in infected mice.
  • To evaluate the roles of microglia and astrocytes in S. parasuis-induced cerebral inflammation.

Main Methods:

  • Infection of mice with S. parasuis clinical strains NN1 and BS26.
  • Monitoring for neurological symptoms and determining their onset.
  • Histopathological examination of brain tissues.
  • Analysis of cerebral immune responses, including glial cell activation.

Main Results:

  • S. parasuis clinical strains NN1 and BS26 induced neurological symptoms in infected mice.
  • Histopathological analysis revealed significant changes in the brain.
  • Activation of microglia and astrocytes was observed, indicating a cerebral immune response.
  • S. parasuis clinical strains show a high potential for inducing early-phase cerebral inflammation.

Conclusions:

  • S. parasuis clinical strains can cause CNS infections and neurological symptoms.
  • These bacteria possess a significant potential to induce cerebral inflammation early in the infection process.
  • The study enhances understanding of S. parasuis pathogenicity and brain inflammatory responses to infection.
Keywords:
S. parasuisTLRsastrocytecerebral inflammationhistopathological changesmicrogliaphagocytosisproinflammatory mediators

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