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Molecular Interactions between APIs and Enteric Polymeric Excipients in Solid Dispersion: Insights from Molecular

Krishna M Gupta1, Xavier Chin1, Parijat Kanaujia1,2

  • 1Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore.

Pharmaceutics
|April 28, 2023
PubMed
Summary

Understanding molecular interactions between drug substances and polymers is key for developing effective solid dispersions. This study used simulations and hot melt extrusion to identify optimal drug-polymer pairs, enhancing drug dissolution and bioavailability.

Keywords:
amorphous formulationhot melt extrusionhydrogen bondinginteraction energymolecular dynamics simulationsolid dispersion

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