Nanomaterial-Based Antivascular Therapy in the Multimodal Treatment of Cancer

Area of Science:

• Oncology
• Nanotechnology
• Biomedical Engineering

Background:

• Abnormal tumor vasculature and hypoxia (TME) impede conventional cancer treatments.
• Antivascular strategies targeting TME and promoting vessel normalization can enhance therapeutic efficacy.
• Nanomaterials offer advantages for efficient drug delivery and multimodal cancer therapy with reduced toxicity.

Purpose of the Study:

• To review nanomaterial-based strategies for antivascular therapy combined with other cancer treatments.
• To highlight the synergistic potential of combining antivascular therapy with immunotherapy, chemotherapy, phototherapy, radiotherapy, and interventional therapy.
• To provide a reference for developing multifunctional nanotheranostic platforms for enhanced antivascular therapy.

Main Methods:

• Literature review of nanomaterial-based antivascular therapy strategies.
• Analysis of combined therapeutic regimens including immunotherapy, chemotherapy, phototherapy, radiotherapy, and interventional therapy.
• Discussion of nanodrug administration for intravascular therapy and other treatments.

Main Results:

• Nanomaterials enable efficient delivery of multiple therapeutic agents for combined cancer treatments.
• Antivascular strategies integrated with other therapies show synergistic antitumor effects.
• Nanodrugs can be utilized for combined intravascular and other therapeutic approaches.

Conclusions:

• Nanomaterial-based antivascular therapy holds significant promise for combined cancer treatment.
• Multifunctional nanotheranostic platforms are crucial for effective antivascular therapy in combination regimens.
• This review provides a foundation for future development in nanomedicine for cancer therapy.