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Single-Strain Probiotic Lactobacilli for the Treatment of Atopic Dermatitis in Children: A Systematic Review and

Sabina Fijan1, Nina Kolč2, Metka Hrašovec2

  • 1Faculty of Health Sciences, University of Maribor, Žitna ulica 15, 2000 Maribor, Slovenia.

Pharmaceutics
|April 28, 2023
PubMed

Insights

Single-strain probiotic lactobacilli significantly reduced atopic dermatitis severity in children. Specific strains like Limosilactobacillus fermentum, longer treatment durations, and younger patient ages improved outcomes, highlighting the importance of tailored probiotic selection.

Area of Science:

  • Microbiology and Immunology
  • Pediatric Dermatology

Background:

  • Probiotics influence gut microbiota and immune system development.
  • Infant gut and skin colonization may impact atopic dermatitis (AD) risk.
  • Evidence suggests probiotics could aid in AD prevention and treatment.

Purpose of the Study:

  • To systematically review and evaluate the efficacy of single-strain probiotic lactobacilli in treating childhood atopic dermatitis.
  • To identify specific probiotic strains, treatment durations, and patient ages associated with improved AD outcomes.

Main Methods:

  • Systematic review and meta-analysis of 17 randomized placebo-controlled trials.
  • Included trials focused on single-strain lactobacilli and the Scoring Atopic Dermatitis (SCORAD) index.
  • Searches conducted in major databases (PubMed, Web of Science, etc.) until October 2022; quality assessed using Joanna Briggs Institute tools.

Main Results:

  • Meta-analysis of 14 trials (1124 children) showed single-strain lactobacilli significantly reduced SCORAD index compared to placebo (MD: -4.50, p=0.003).
  • Subgroup analysis indicated Limosilactobacillus fermentum strains were more effective than L. plantarum, L. paracasei, or L. rhamnosus.
  • Longer treatment duration and younger patient age were associated with statistically significant symptom reduction.

Conclusions:

  • Certain single-strain probiotic lactobacilli demonstrate significant efficacy in reducing atopic dermatitis severity in children.
  • Strain selection (e.g., L. fermentum), treatment duration, and patient age are critical factors for optimizing probiotic therapy effectiveness.
  • Targeted probiotic interventions hold promise for managing childhood atopic dermatitis.

Keywords:
atopic dermatitischildrenlactobacillimeta-analysisprobioticssystematic review

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