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Inflammatory markers in children with obstructive sleep apnea syndrome

Yingge Wang1,2,3, Ying Chen4, Wei Lin1,2,3

  • 1Department of Otorhinolaryngology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Frontiers in Pediatrics
|April 28, 2023
PubMed

Insights

Children with Obstructive Sleep Apnea Syndrome (OSAS) exhibit elevated serum inflammatory markers, including YKL-40 and Interleukin-8 (IL-8). These markers show potential for diagnosing OSAS in pediatric patients.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Immunology

Background:

  • Obstructive Sleep Apnea Syndrome (OSAS) is increasingly diagnosed in children.
  • Systemic inflammation is implicated in the pathophysiology of OSAS.
  • Biomarkers for OSAS diagnosis and monitoring are actively sought.

Purpose of the Study:

  • To evaluate serum inflammatory markers in children with and without OSAS.
  • To assess YKL-40, Interleukin-6 (IL-6), Interleukin-8 (IL-8), Interleukin-10 (IL-10), Tumor Necrosis Factor-alpha (TNF-α), and C-reactive protein (CRP).

Main Methods:

  • Enzyme-Linked Immunosorbent Assay (ELISA) was used to measure serum inflammatory marker concentrations.
  • Study included 83 children diagnosed with OSAS and 83 healthy controls.
  • Correlations between markers and OSAS severity (OAHI, LoSpO2%) were analyzed.

Main Results:

  • Serum levels of YKL-40, IL-6, IL-8, and IL-10 were significantly increased in children with OSAS.
  • YKL-40 showed positive correlations with IL-6, IL-8, OAHI, and LoSpO2%, and a negative correlation with IL-10.
  • IL-8 correlated positively with OAHI, and IL-10 with LoSpO2%.

Conclusions:

  • Children with OSAS experience a state of systemic inflammation.
  • YKL-40 and IL-8 may serve as valuable serum biomarkers for OSAS diagnosis in children.
  • Further research can explore their role in OSAS management.
Abstract

Keywords:
OSA (Obstructive sleep apnea)YKL-40inflammatory factorsinterleukinobstructive sleep apnea syndrome

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