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The Roles of Microtubule-Associated Protein 4 in Wound Healing and Human Diseases

Qiquan Chen1, Junhui Zhang2, Zhiqiang Song1

  • 1Department of Dermatology, Southwest Hospital, Third Military Medical University (Army Medical University), 400038 Chongqing, China.

Frontiers in Bioscience (Landmark Edition)
|April 28, 2023
PubMed

Insights

Microtubule-associated protein 4 (MAP4) regulates microtubule stability, impacting cell activities and human diseases. This review highlights MAP4

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Microtubules (MTs) are crucial for cell structure and function.
  • Microtubule-associated proteins (MAPs) regulate MT assembly and stability.
  • MAP4 is a key MAP involved in maintaining MT stability across various cell types.

Purpose of the Study:

  • To review the detailed regulatory mechanisms of MAP4 in MT stability.
  • To focus on MAP4's role in wound healing and human diseases.
  • To highlight MAP4 as a potential therapeutic target.

Main Methods:

  • Literature review of studies on MAP4 and MT stability.
  • Analysis of signaling pathways affected by MAP4.
  • Examination of MAP4's role in disease pathogenesis.

Main Results:

  • MAP4 ubiquitously regulates MT stability in neuronal and non-neuronal cells.
  • MAP4 influences cell activities through MT stability and signaling pathways.
  • MAP4 is implicated in the pathogenesis of various human disorders.

Conclusions:

  • MAP4's mechanisms in regulating MT stability are well-established.
  • MAP4 plays significant roles in wound healing and disease.
  • MAP4 presents a promising therapeutic target for healing and disease treatment.
Keywords:
human diseasesmicrotubulemicrotubule dynamicsmicrotubule stabilitymicrotubule-associated protein 4wound healing

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