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Updated: Aug 1, 2025

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
Published on: February 25, 2022
Recent advances in the role of exosomes in liver fibrosis
Jiliang Shen1, Jiasheng Cao1, Mingyu Chen1
1Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background And Aim:
We aim to summarize the current status of research on the role of exosomes in liver fibrosis.
Methods:
A review of the relevant literature was performed and the key findings were presented.
Results:
Most studies focused on the role of exosomes derived from mesenchymal stem cells, other types of stem cells, and liver resident cells including hepatocytes, cholangiocytes, and hepatic stellate cells in liver fibrosis. Exosomes have been reported to play an essential role in the inactivation or activation of hepatic stellate cells through the delivery of non-coding RNAs and proteins. In recent years, this exosome cargo has become a research hotspot.
Conclusions:
Recent studies have indicated the potential therapeutic benefit of exosomes in liver fibrosis.
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