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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

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Pancreatic Tumor-Targeting Stemsome Therapeutics.

Jun-Young Park1, Jun Young Park2, Yong-Gyu Jeong2

  • 1Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 21999, South Korea.

Advanced Materials (Deerfield Beach, Fla.)
|April 28, 2023
PubMed
Summary

Stem cell membranes functionalized onto nanocarriers effectively target pancreatic cancer. This novel approach delivers anticancer drugs like doxorubicin to deep tumors, offering a new strategy for intractable cancers.

Keywords:
PLGA nanoparticlesectosomespancreatic cancerstem cellssurface target receptorstumor targeting

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Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Pancreatic cancer is a challenging tumor with limited treatment options.
  • Stem cells possess inherent tumor-targeting capabilities.
  • Developing effective drug delivery systems for deep-seated tumors remains a significant challenge.

Purpose of the Study:

  • To develop a novel nanocarrier system for targeting pancreatic cancer.
  • To leverage stem cell membranes for enhanced tumor homing.
  • To investigate the potential of stem-cell-membrane-functionalized nanocarriers for delivering anticancer drugs to deep tumors.

Main Methods:

  • Stem cell membranes were used to functionalize nano-polylactide-co-glycolide (PLGA) nanocarriers.
  • Doxorubicin was loaded into the functionalized nanocarriers.
  • The targeting ability of these nanocarriers against pancreatic cancer cells was evaluated.
  • The efficacy of the drug-loaded nanocarriers in reducing deep pancreatic tumor tissues was assessed.

Main Results:

  • Stem-cell-membrane-functionalized nanocarriers demonstrated effective targeting of pancreatic cancer cells.
  • The nanocarriers successfully delivered doxorubicin to deep tumor tissues.
  • The strategy showed potential for treating intractable pancreatic tumors.

Conclusions:

  • Stem-cell-membrane-functionalized nanocarriers represent a promising platform for pancreatic cancer therapy.
  • This approach offers a potential strategy for targeting tumors lacking specific surface receptors.
  • The technology could be extended to target other malignant tumors.