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Updated: Aug 1, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
A three component 1,3-difunctionalization of vinyl diazo esters enabled by a cobalt catalyzed C-H activation/carbene
Nandkishor Prakash Khot1, Prajyot Jayadev Nagtilak1, Nitish Kumar Deo1
1Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal By-pass Road, Bhopal 462066, Madhya Pradesh, India. mk@iiserb.ac.in.
Abstract:
We report herein, a modular, regioselective 1,3-oxyarylation of vinyl diazo esters via a Co-catalyzed C-H activation/carbene migratory insertion cascade. The transformation involves the formation of C-C and C-O bonds in a one-pot fashion and displays a broad substrate scope with respect to both, vinyl diazo esters as well as benzamides. The coupled products were subjected to hydrogenation to access elusive allyl alcohol scaffolds. Mechanistic investigations reveal interesting insights on the mode of transformation, involving C-H activation, carbene migratory insertion of the diazo compound followed by a radical addition as the key steps of the transformation.
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