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Glucose-decorated engineering platelets for active and precise tumor-targeted drug delivery
Jiaxuan Zhao1, Yan Shi1, Lixia Xue2
1College of Marine Life Science, Ocean University of China, 5 Yushan Road, 266003, Qingdao, China. kongming@ouc.edu.cn.
Biomaterials Science
|April 28, 2023
Summary
Engineered platelets decorated with glucose (DPG-PLs) target tumors by binding to GLUT1-overexpressing cells. These novel drug delivery systems show enhanced antitumor effects, particularly in tumor bleeding models, offering precise therapeutic solutions.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Precise targeted drug delivery is essential for effective tumor therapy.
- Cell-based delivery systems offer improved biocompatibility and reduced immunogenicity.
- Platelets are emerging as promising natural carriers for targeted drug delivery.
Purpose of the Study:
- To engineer glucose-decorated platelets (DPG-PLs) for enhanced tumor targeting.
- To investigate the payload release mechanism of DPG-PLs in the tumor microenvironment.
- To evaluate the antitumor efficacy of doxorubicin-loaded DPG-PLs (DPG-PL@DOX) in a preclinical model.
Main Methods:
- Constructed DPG-PLs via cell membrane fusion with DSPE-PEG-Glucose (DPG).
- Verified glucose decoration and assessed platelet structural and functional integrity.
- Evaluated DPG-PL binding affinity to GLUT1-overexpressing tumor cells.
- Assessed antitumor effects of DPG-PL@DOX in a mouse melanoma model, including a tumor bleeding model.
Main Results:
- DPG-PLs maintained resting state integrity and demonstrated enhanced binding to GLUT1-positive tumor cells.
- DPG-PL@DOX exhibited potent antitumor activity in a mouse melanoma model.
- Antitumor effects were significantly amplified in the tumor bleeding model, highlighting synergistic potential.
Conclusions:
- Glucose-decorated platelets (DPG-PLs) represent an effective strategy for active and precise tumor-targeted drug delivery.
- DPG-PL@DOX shows significant potential for enhancing cancer therapy, especially in postoperative settings.
- This approach offers a novel solution for improving therapeutic outcomes in cancer treatment.
