Related Experiment Video
Updated: Aug 1, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
Published on: February 16, 2022
COVID-19 infection and seroconversion rates in healthcare workers in Lebanon: An observational study
Mariana Helou1, Sanaa Zoghbi2, Nour El Osta1
1Division of Emergency, Department of Internal Medicine, Lebanese American University, School of Medicine, Beirut, Lebanon.
Insights
A study found that 19.7% of healthcare workers (HCW) developed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. Seropositivity varied by role, with housekeeping staff showing the highest rates, highlighting the need for better HCW protection.
Area of Science:
- Infectious Diseases
- Epidemiology
- Occupational Health
Background:
- Coronavirus disease 2019 (COVID-19) poses a significant risk to healthcare workers (HCW).
- Seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varies among HCW populations.
- Understanding seroconversion rates is crucial for assessing infection risk and implementing protective measures.
Purpose of the Study:
- To determine the prevalence of SARS-CoV-2 antibodies and seroconversion among HCW in a hospital setting.
- To identify risk factors associated with seropositivity within different hospital departments.
- To inform public health policies for HCW protection during the COVID-19 pandemic.
Main Methods:
- A cross-sectional study involving 203 HCW.
- Serological testing for SARS-CoV-2 antibodies.
- Analysis of seroconversion rates and seropositivity by gender and occupational group.
Main Results:
- Overall seroconversion rate was 19.7%.
- Seropositivity was higher in males (25%) than females (13.4%).
- Highest seropositivity rates observed in Housekeeping (83%) and COVID Floor (45%) staff; lowest in Anesthesia (4%) and Infection Control (0%).
- Prolonged patient contact correlated with higher seropositivity on COVID floors and ICUs.
- Consistent N95 mask use was associated with lower seropositivity in inhalation and anesthesia teams.
Conclusions:
- COVID-19 seropositivity among HCW is a significant public health concern.
- Occupational roles and adherence to protective measures influence infection risk.
- Enhanced protective policies are necessary to safeguard HCW during pandemics.
Abstract:
Coronavirus disease 2019 (COVID-19) infection is a recent pandemic. Healthcare workers (HCW) are at high risk of acquiring the infection and transmitting it to others. Seroprevalence for COVID-19 among HCW varies between countries, hospitals in the same country and even among different departments in the same hospital. In this study, we aim to determine the prevalence of severe acute respiratory syndrome coronavirus 2 antibodies and the seroconversion among the HCW in our hospital. A total of 203 HCW were included. The rate of conversion to seropositive was 19.7% in total, with a rate of 13.4% in female versus 25% in male. The seropositivity in the House keeping group was 83%, followed by 45% in the COVID Floor while the seropositivity in the Anesthesia was 4% and the Infection Control 0%. The highest seropositivity rate in the COVID floor, and in the intensive care unit was explained by the long time spent with the patients. While in the inhalation team and the anesthesia, the lower rates of seropositivity was due to the N95 mask wearing the whole time. Seropositivity for COVID-19 in HCW is a major public health concern. Policies should be implemented to better protect HCWs.
More Related Videos
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Standard Precaution
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Transmission-based Precautions II: Airborne and Protective Environment
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...

