Correction: Formal synthesis of cyclotheonellazole A
Bohua Long1,2, Liu-Yang Pu1,2, Zhanyan Liu1,2
1Shenzhen Institute of Translational Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China. szwzz001@163.com.
This correction addresses errors in the formal synthesis of cyclotheonellazole A, a complex marine natural product. The revised details ensure accurate reporting of synthetic strategies and characterization data.
Area of Science:
- Organic Chemistry
- Natural Product Synthesis
- Medicinal Chemistry
Context:
- The original publication detailed the formal synthesis of cyclotheonellazole A.
- Cyclotheonellazole A is a complex marine alkaloid with potential biological activity.
- Accurate reporting is crucial in chemical synthesis publications.
Purpose:
- To correct inaccuracies in the previously published formal synthesis of cyclotheonellazole A.
- To provide revised experimental details and characterization data.
- To ensure the integrity and reproducibility of the reported synthetic route.
Summary:
- This correction addresses specific errors identified in the formal synthesis of cyclotheonellazole A.
- The revised information pertains to synthetic steps, reaction conditions, and spectroscopic data.
- The correction ensures the accuracy of the chemical structures and synthetic pathways presented.
Impact:
- Ensures the reliability of the chemical literature regarding cyclotheonellazole A synthesis.
- Facilitates future research efforts building upon this synthetic work.
- Upholds scientific rigor and reproducibility in organic synthesis.
Related Concept Videos
Cycloaddition Reactions: Overview
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Stability of Substituted Cyclohexanes
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Cycloaddition Reactions: MO Requirements for Thermal Activation
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Conformations of Cyclohexane
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...


