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Updated: Aug 1, 2025
08:52
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
3.6K
Cellular senescence and neurodegeneration.
Kristopher Holloway1, Kashfia Neherin1, Kha Uyen Dam1
1Department of Pediatrics, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.
Human Genetics
|April 28, 2023
Summary
Cellular senescence, a hallmark of aging, contributes to Alzheimer's disease (AD) pathogenesis. Eliminating senescent cells in mouse models improved AD pathologies and cognition, highlighting senescence as a therapeutic target.
Area of Science:
- Gerontology and Neuroscience
- Cellular Biology and Aging
- Neurodegenerative Disease Research
Background:
- Advancing age is a primary risk factor for Alzheimer's disease (AD), affecting millions globally.
- Molecular mechanisms linking aging to cognitive decline in AD are not fully understood.
- Cellular senescence, a key aging process, is implicated in age-related diseases, including AD.
Purpose of the Study:
- To review the role of cellular senescence in Alzheimer's disease pathogenesis.
- To discuss recent advances in understanding how cellular senescence impacts AD.
- To explore the potential role of cellular senescence in other neurodegenerative conditions.
Main Methods:
- Review of existing literature on cellular senescence and Alzheimer's disease.
- Analysis of studies investigating senescent cell accumulation in AD brains.
- Examination of research on the effects of senescent cell elimination in AD models.
Main Results:
- Senescent neurons and glial cells are found in the brains of AD patients and models.
- Selective elimination of senescent cells reduces amyloid and tau pathologies in AD mouse models.
- Cognitive function is improved in AD mouse models following senescent cell clearance.
Conclusions:
- Cellular senescence plays a critical role in the pathogenesis of Alzheimer's disease.
- Targeting senescent cells represents a promising therapeutic strategy for AD.
- Further research is needed to elucidate the precise mechanisms and timing of senescence's contribution to AD.
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