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Fusarium solani: prevalence of skin reactivity and antigenic allergenic analysis

C E O'Neil, M L McCants, J E Salvaggio

    The Journal of Allergy and Clinical Immunology
    |June 1, 1986
    PubMed

    Insights

    This study found that 24.5% of atopic individuals showed positive skin reactions to Fusarium solani mold extracts, indicating its role in mold allergy. These extracts contain multiple allergens with varying molecular weights.

    Area of Science:

    • Allergy and Immunology
    • Mycology
    • Biochemistry

    Background:

    • Mold allergy is a significant health concern for atopic individuals.
    • Fusarium solani is a common mold species found in various environments.

    Purpose of the Study:

    • To determine the prevalence of reactivity to Fusarium solani in atopic individuals with mold allergy symptoms.
    • To evaluate the allergenic and antigenic properties of F. solani extracts.

    Main Methods:

    • Skin prick testing and Radioallergosorbent Test (RAST) were used to assess reactivity in atopic individuals.
    • Immunoelectrophoresis was employed to determine antigenic and allergenic activity.
    • Gel filtration chromatography (Bio-Gel A 0.5 m) was used to analyze the molecular weight of allergens.

    Main Results:

    • 24.5% of the tested atopic individuals (n=69) exhibited positive skin reactions to F. solani extract.
    • Skin test results showed a statistical correlation with RAST findings.
    • F. solani extract demonstrated both antigenic properties in rabbits and allergenic potential in humans.
    • Gel filtration revealed three distinct peaks of ultraviolet-absorbing material, with the highest RAST inhibition activity linked to a protein peak >341 kDa.

    Conclusions:

    • Fusarium solani extracts contain multiple allergens responsible for allergic reactions.
    • These allergens vary in molecular weight and charge, suggesting complex allergenic components.
    • F. solani is a relevant allergen for individuals with mold allergies.

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