Related Experiment Video
Updated: Aug 1, 2025

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
Published on: August 16, 2017
The Role of Extracellular Matrix in Wound Healing
Pingping Lin1,2,3,4, Guohong Zhang5, Hang Li1,2,3,4
1Department of Dermatology and Venereology, Peking University First Hospital, Beijing, China.
Background:
Extracellular matrix communicates with surrounding cells to maintain skin homeostasis and modulate multiple cellular processes including wound healing.
Objective:
To elucidate the dynamic composition and potential roles of extracellular matrix in normal skin, wound healing process, and abnormal skin scarring.
Materials And Methods:
Literature review was performed to identify relevant publications pertaining to the extracellular matrix deposition in normal skin and wound healing process, as well as in abnormal scars.
Results:
A summary of the matrix components in normal skin is presented. Their primary roles in hemostasis, inflammation, proliferation, and remodeling phases of wound healing are briefly discussed. Identification of novel extracellular matrix in keloids is also provided.
Conclusion:
Abnormal scarring remains a challenging condition with unmet satisfactory treatments. Illumination of extracellular matrix composition and functions in wound healing process will allow for the development of targeted therapies in the future.
More Related Videos
07:53Establishment of a Clinically Relevant Ex Vivo Mock Cataract Surgery Model for Investigating Epithelial Wound Repair in a Native Microenvironment
Published on: June 5, 2015
06:01Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture
Published on: February 2, 2019
Related Concept Videos
The Extracellular Matrix
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Extracellular Matrix
Role of Matrix Metalloproteases in Degradation of ECM
Overview of Cell-Matrix Interactions
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...