Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spiky Magnetic Titania Particles for Integrated Exosome Capture and Metabolic Profiling Toward Cancer Diagnosis.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Nanozyme-Reinforced miR-197-3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026

Same author

Cartilage targeted grape skin-derived extracellular vesicles ameliorate osteoarthritis by attenuating chondrocyte senescence.

Journal of nanobiotechnology·2026

Same author

Radially Aligned Microchannels in a Hemostatic Sponge: Orchestrating Directional Transport, Active Sieving, and Coagulation.

Advanced healthcare materials·2026

Same author

Ultrasound-stimulated BTO-BSA-gen inhibits implant-associated infections by suppressing bacterial adhesion and potentiating aminoglycosides.

Journal of nanobiotechnology·2026

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Harnessing Nucleic Acids Nanotechnology for Bone/Cartilage Regeneration.

Yafei Han¹, Liehu Cao², Guangfeng Li³

¹Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.

Small (Weinheim an Der Bergstrasse, Germany)

|April 28, 2023

Summary

Nucleic acid nanotechnology offers a promising new approach for regenerating bone and cartilage defects. This innovative biomaterial strategy addresses limitations of traditional grafting methods for tissue repair.

Keywords:

biomaterials bone/cartilage regeneration deoxyribonucleic acid/ribonucleic acid nanotechnology nucleic acids

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Related Experiment Videos

Last Updated: Jun 19, 2026

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

Published on: April 19, 2015

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

Area of Science:

Biomaterials Science
Nanotechnology
Regenerative Medicine

Background:

Bone and cartilage regeneration for significant defects is a major clinical challenge.
Current treatments like bone grafting have limitations in achieving desired outcomes.
Nucleic acids offer unique nanoscale design capabilities for therapeutic applications.

Purpose of the Study:

To review the application of nucleic acid nanotechnology in bone and cartilage regeneration.
To explore the potential of nucleic acid-based biomaterials for tissue repair.
To identify challenges and future directions in this field.

Main Methods:

Literature review of nucleic acid nanotechnology applications in regenerative medicine.
Analysis of the design principles and functional programming of nucleic acids at the nanoscale.
Evaluation of in-cell and in vivo potential for biomaterial development.

Main Results:

Nucleic acid nanotechnology enables the creation of structured nanomaterials with specific functions.
These nanomaterials show promise for in-cell and in vivo applications in tissue regeneration.
The technology offers advantages over traditional bone grafting techniques.

Conclusions:

Nucleic acid nanotechnology presents a novel and promising avenue for bone and cartilage regeneration.
Further research is needed to overcome challenges and fully realize the potential of this technology.
This approach holds significant promise for advancing biomaterials in regenerative medicine.