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Benign prostatic hyperplasia associated with white matter hyperintensities in men
Fang Yin1, Qi-Da He2, Jing Chen3
1Division of Nephrology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, PR China.
Clinical Neurology and Neurosurgery
|April 28, 2023
Summary
Benign prostatic hyperplasia (BPH) is linked to white matter hyperintensities (WMHs) in men. This study found a significant association between BPH and cerebral white matter changes.
Area of Science:
- Neurology
- Urology
- Public Health
Background:
- Benign prostatic hyperplasia (BPH) is a common condition causing prostate enlargement and lower urinary tract symptoms.
- BPH is associated with an increased risk of cerebrovascular diseases, including stroke.
- White matter hyperintensities (WMHs) are indicators of cerebral injury and are linked to stroke, cognitive decline, and mortality.
Purpose of the Study:
- To investigate the association between benign prostatic hyperplasia (BPH) and white matter hyperintensities (WMHs).
Main Methods:
- A cross-sectional study involving 788 male patients was conducted.
- Benign prostatic hyperplasia (BPH) was diagnosed using abdominal ultrasound.
- White matter hyperintensities (WMHs) were assessed by neuroradiologists, and logistic regression was employed to analyze the data.
Main Results:
- Patients with benign prostatic hyperplasia (BPH) showed a significantly increased risk of white matter hyperintensities (WMHs).
- The crude odds ratio for WMHs in BPH patients was 2.76 (95% CI, 2.02-3.79).
- After adjusting for confounding factors, the adjusted odds ratio remained significant at 1.75 (95% CI, 1.24-2.48).
Conclusions:
- Benign prostatic hyperplasia (BPH) is closely associated with white matter hyperintensities (WMHs) in the studied male Chinese population.
- This finding suggests a potential link between prostate health and cerebral white matter integrity.
