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Published on: December 27, 2016
Staphylococcal biofilm: penetration and bioavailability of vancomycin with or without rifampin
Kathryn E Daffinee1, Emily T O'Neill2, Callan R Bleick3
1Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA.
Abstract:
We measured antibiotic penetration and bioavailability in staphylococcus biofilms using simulated humanized concentrations of fluorescent vancomycin plus or minus rifampin. Vancomycin percent recovery across biofilm layers was:upper = 46%, middle = 40%, and lower = 33%. Vancomycin plus rifampin was not significantly different (P = 0.65). Addition of rifampin did not improve vancomycin penetration across biofilm layers.
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