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Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular

Yu Wen1, Shichun Lun2, Yuxue Jiao1

  • 1Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.

European Journal of Medicinal Chemistry
|April 28, 2023
PubMed

Keywords:
MDR and XDR tuberculosisMmpL3Pyridine-2-methylamineStructure-based drug design

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The simplest aromatic amine is phenylamine, which contains an –NH2 functionality directly attached to an aromatic ring. The name aniline is designated for this skeleton. As shown in Figure 1, the common names of the functionalized anilines involve prefixes ortho-, meta-, and para- to indicate the substitution position. Different functionalized aniline derivatives also have notable trivial names.
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