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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Partial Breast Irradiation.

Icro Meattini1, Rejane de Oliveira Franco2, Viola Salvestrini1

  • 1Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy; Radiation Oncology Unit, Oncology Department, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.

Breast (Edinburgh, Scotland)
|April 28, 2023
PubMed
Summary
This summary is machine-generated.

Partial breast irradiation offers a reduced toxicity approach for early-stage breast cancer patients. This strategy aims to maintain oncologic outcomes by focusing radiation dose near the tumor bed, balancing effectiveness and patient well-being.

Keywords:
Breast cancerOncologyPartial breast irradiationRadiation therapyRadiotherapy

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Area of Science:

  • Oncology
  • Radiation Therapy
  • Breast Cancer Research

Background:

  • Breast cancer is a leading global cancer in women, necessitating personalized treatment strategies.
  • Current early-stage breast cancer treatment involves postoperative whole breast irradiation, achieving low recurrence rates.
  • Reducing treatment morbidity while preserving efficacy remains a key challenge in radiation oncology.

Purpose of the Study:

  • To provide a comprehensive overview of partial breast irradiation (PBI) in breast cancer management.
  • To discuss the advantages, risks, techniques, and current recommendations for PBI.
  • To support clinical decision-making by exploring practical findings and future perspectives in breast cancer treatment optimization.

Main Methods:

  • Review of national and international guidelines on partial breast irradiation.
  • Analysis of dose/fractionation schedules and eligibility criteria for PBI.
  • Exploration of various PBI techniques and their associated outcomes.

Main Results:

  • Postoperative whole breast irradiation shows recurrence rates below 4% outside the initial tumor bed.
  • Partial breast irradiation strategies aim to reduce treatment toxicity without compromising oncologic outcomes.
  • Evidence suggests that the dose delivered to tissue neighboring the tumor bed is crucial for irradiation benefits.

Conclusions:

  • Breast cancer is a heterogeneous disease requiring individualized treatment, not a one-size-fits-all approach.
  • Partial breast irradiation presents a viable option for reducing morbidity in select early-stage breast cancer patients.
  • Further research and clinical evaluation are needed to optimize PBI for balancing oncologic control and treatment toxicity.