Hydrodynamic considerations for spring-driven autoinjector design
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Updated: Aug 1, 2025

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
Published on: September 2, 2009
Xiaoxu Zhong1, Jean-Christophe Veilleux2, Galen Huaiqiu Shi2
1School of Mechanical Engineering, Purdue University, West Lafayette, IN 47906, United States.
Abstract:
In recent years, significant progress has been made in the studies of the spring-driven autoinjector, leading to an improved understanding of this device and its interactions with tissue and therapeutic proteins. The development of simulation tools that have been validated against experiments has also enhanced the prediction of the performance of spring-driven autoinjectors. This paper aims to address critical hydrodynamic considerations that impact the design of spring-driven autoinjectors, with a specific emphasis on sloshing and cavitation. Additionally, we present a framework that integrates simulation tools to predict the performance of spring-driven autoinjectors and optimize their design. This work is valuable to the pharmaceutic industry, as it provides crucial insights into the development of spring-driven autoinjectors and therapeutic proteins. This work can also enhance the efficacy and safety of the delivery of therapeutic proteins, ultimately improving patient outcomes.
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