Reduced duration mismatch negativity elicited by the multi-feature 'optimal' paradigm in early-phase psychosis
Hayley Riel1, Erica D Rudolph2, Catrina MacPhee1
1Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Background:
MMN and P3a are EEG-derived event related potentials that are thought to be prospective biomarkers for schizophrenia and, potentially, early-phase psychosis (EPP).
Methods:
EPP (n = 12) and healthy control (HC; n = 35) participants listened to a multi-feature optimal paradigm with five deviant types (gap, duration, location, intensity, and frequency).
Results:
There was a significant amplitude difference between the EPP and HC group with duration MMN (p = .02). No significant amplitude differences between groups were found for the P3a waveform. There were several correlations for the EPP group with the BNSS, SOFAS, and PANSS-general questionnaires. Length of illness was not associated with MMN or P3a.
Conclusions:
The optimal paradigm is suitable for eliciting multiple deviant types within a short amount of time in both clinical and healthy populations. This study confirms duration MMN deficits within an EPP group and that MMN is related to functional outcomes and positive and negative symptomology.
More Related Videos
12:00Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
09:52How to Find Effects of Stimulus Processing on Event Related Brain Potentials of Close Others when Hyperscanning Partners
Published on: May 31, 2018
Related Concept Videos
01:26Psychosis: Goals of Pharmacotherapy
01:28Psychosis and Antipsychotic Drugs: Overview