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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience
  • Ophthalmology

Background:

  • Next-generation neural interfaces require shape-morphable electrode arrays for consistent positioning on complex neural anatomy.
  • Retinal prostheses demand curved interfaces to match the spherical eye and broad coverage to restore peripheral vision.

Purpose of the Study:

  • To fabricate a full-field retinal array with shape-morphable properties for implantation into the eye.
  • To assess the array's ability to conform to the ocular surface and cover a significant visual field.
  • To evaluate the feasibility of surgical implantation via a minimally invasive approach.

Main Methods:

  • Fabrication of a multi-layered polymer structure (elastomer/polyimide-electrode/elastomer) coated with hydrogel.
  • Electrodeposition of platinum/iridium alloy to enhance electrode surface area and electrical properties.
  • Testing of the array's ability to fold, implant into ex vivo pig eyes, and self-deploy into a curved shape.

Main Results:

  • The full-field array demonstrated the capacity to fold for implantation and self-deploy into a 3D curved surface within ex vivo pig eyes.
  • The device offers coverage for a 57° visual field (electrode position) and 113° (substrate size).
  • Electrodes with platinum/iridium alloy showed improved performance, even with hydrogel over-coating.

Conclusions:

  • The developed shape-changing material platform enables the creation of conformable neural interfaces.
  • The full-field retinal array facilitates significant retinal coverage and implantation through a small surgical incision (33% of device diameter).
  • This technology holds promise for advanced retinal prostheses and other neural interfaces requiring anatomical conformity.