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Non-covalent interactions (NCIs) are revolutionizing synthetic carbohydrate chemistry. Harnessing NCIs offers a powerful strategy for selective glycosidic bond formation and glycofunctionalizations, addressing key challenges in the field.

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Area of Science:

  • Organic Chemistry
  • Carbohydrate Chemistry
  • Supramolecular Chemistry

Background:

  • Non-covalent interactions (NCIs) are fundamental to biological processes.
  • Their application in synthetic chemistry, particularly carbohydrate chemistry, is a rapidly growing area.
  • NCIs offer novel solutions for selectivity challenges in glycosylation.

Purpose of the Study:

  • To provide a comprehensive overview of advances in using NCIs in synthetic carbohydrate chemistry.
  • To highlight the role of NCIs in catalysis, selectivity, and stabilization.
  • To explore emerging opportunities with unconventional NCIs.

Main Methods:

  • Review of recent literature on non-covalent catalysis in glycosylation and glycofunctionalization.
  • Analysis of NCIs in aglycone delivery and stabilization of reaction intermediates.
  • Examination of hydrogen bonding, halogen bonding, and other non-conventional NCIs.

Main Results:

  • NCIs enable efficient and selective glycosylations and glycofunctionalizations.
  • Non-covalent catalysis, hydrogen bonding, and aglycone delivery are key applications.
  • Emerging interactions like halogen bonding offer new synthetic possibilities.

Conclusions:

  • Harnessing NCIs is a transformative strategy in modern carbohydrate synthesis.
  • This approach provides robust solutions for anomeric and site selectivity.
  • Further exploration of diverse NCIs promises continued innovation in the field.