Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

3.3K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.3K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

2.3K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
2.3K
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

8.4K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
8.4K
Non-gated Ion Channels01:24

Non-gated Ion Channels

6.9K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
6.9K
Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

3.4K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.4K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

6.5K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deubiquitinating Enzyme UCH-L1 Regulates Neuronal Ca<sup>2+</sup> Signaling.

ACS chemical neuroscience·2025
Same author

Cellular neurobiology of hyperforin.

Phytotherapy research : PTR·2023
Same author

Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex development.

Molecular brain·2022
Same author

Zinc Uptake and Storage During the Formation of the Cerebral Cortex in Mice.

Molecular neurobiology·2019
Same author

Intracellular Localization of an Osmocenyl-Tamoxifen Derivative in Breast Cancer Cells Revealed by Synchrotron Radiation X-ray Fluorescence Nanoimaging.

Angewandte Chemie (International ed. in English)·2019

Related Experiment Video

Updated: Aug 1, 2025

Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
14:18

Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber

Published on: February 13, 2012

21.3K

Neuronal Store-Operated Calcium Channels.

Alexandre Bouron1

  • 1Université Grenoble Alpes, CNRS, CEA, Inserm UA13 BGE, 38000, Grenoble, France. alexandre.bouron@cea.fr.

Molecular Neurobiology
|April 28, 2023
PubMed
Summary

Store-operated calcium entry (SOCE) is crucial in non-excitable cells. This review confirms SOCE

Area of Science:

  • Neuroscience
  • Cell Biology
  • Calcium Signaling

Background:

  • The endoplasmic reticulum (ER) is a primary intracellular calcium (Ca2+) store in eukaryotic cells.
  • Store-operated calcium entry (SOCE) involves Ca2+ uptake via cell surface channels (SOCCs) after ER Ca2+ store depletion.
  • SOCE is well-established in non-excitable cells but its presence in neurons has been debated.

Purpose of the Study:

  • To review evidence supporting depletion-dependent Ca2+ entry in neurons.
  • To discuss the molecular identity, expression, and properties of neuronal SOCCs.
  • To explore the physiological significance of SOCE in neuronal function.

Main Methods:

  • Review of experimental studies on neuronal calcium signaling.
  • Analysis of data on ER Ca2+ store depletion and subsequent Ca2+ influx.
Keywords:
BrainCalcium channels, Endoplasmic reticulumOraiSTIM

More Related Videos

Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels
07:17

Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels

Published on: December 13, 2024

784
Whole-Cell Recording of Calcium Release-Activated Calcium CRAC Currents in Human T Lymphocytes
15:29

Whole-Cell Recording of Calcium Release-Activated Calcium CRAC Currents in Human T Lymphocytes

Published on: December 21, 2010

16.2K

Related Experiment Videos

Last Updated: Aug 1, 2025

Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
14:18

Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber

Published on: February 13, 2012

21.3K
Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels
07:17

Single-Cell Calcium Imaging for Studying the Activation of Calcium Ion Channels

Published on: December 13, 2024

784
Whole-Cell Recording of Calcium Release-Activated Calcium CRAC Currents in Human T Lymphocytes
15:29

Whole-Cell Recording of Calcium Release-Activated Calcium CRAC Currents in Human T Lymphocytes

Published on: December 21, 2010

16.2K
  • Examination of molecular, pharmacological, and functional evidence for neuronal SOCCs.

    • Main Results:

    • Growing evidence supports the existence of SOCE in neurons.
    • Neuronal SOCCs are recruited following ER Ca2+ store depletion.
    • Studies indicate specific molecular compositions and physiological roles for neuronal SOCE.

    Conclusions:

    • Neuronal SOCE is a significant Ca2+ influx pathway.
    • Understanding neuronal SOCCs is vital for comprehending neuronal physiology.
    • This pathway represents a key target for future research and therapeutic interventions.