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Related Concept Videos

Insulin Formulations: Types and Delivery01:27

Insulin Formulations: Types and Delivery

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

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The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

162
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Updated: Aug 1, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Long-Acting Injectable Aqueous Suspensions-Summary From an AAPS Workshop.

René Holm1, Robert W Lee2, Joey Glassco3

  • 1Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark. reho@sdu.dk.

The AAPS Journal
|April 28, 2023
PubMed
Summary
This summary is machine-generated.

Long-acting injectable formulations, particularly aqueous suspensions, offer improved patient convenience and treatment efficacy for various diseases. Further research into formulation and manufacturing is needed to unlock their full potential.

Keywords:
PBPK modellingaqueous suspensionsin vitro dissolutionlong-acting injectablesmanufacturing

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Long-acting injectables (LAIs) have a proven track record of enhancing patient convenience.
  • LAIs offer a more effective treatment compared to conventional formulations.
  • The potential of LAIs to improve patient quality of life across diverse diseases is significant.

Purpose of the Study:

  • To summarize key discussions from a workshop focused on aqueous suspension LAIs.
  • To provide insights into the current understanding, learnings, and knowledge gaps in LAI development.
  • To highlight the formulation and manufacturing aspects of LAIs.

Main Methods:

  • Review of central talks from a dedicated workshop.
  • Focus on aqueous suspension formulations for long-acting injectables.
  • Exploration of formulation, manufacturing, dissolution methods, and correlation studies.

Main Results:

  • Aqueous suspensions represent a promising LAI formulation approach.
  • Key elements discussed include formulation design, manufacturing processes, and in vitro dissolution testing.
  • In vitro-in vivo correlation and in silico modeling are crucial for understanding LAI performance.

Conclusions:

  • LAIs, especially aqueous suspensions, offer substantial benefits in patient care.
  • Understanding formulation and manufacturing is vital for optimizing LAI efficacy.
  • Further research is needed to address existing gaps in LAI technology and application.