Brain histamine metabolism in transmissible spongiform encephalopathy (scrapie)

The histamine (Hi) content and the activity of L-histidine decarboxylase (HD) in brains of scrapie infected hamsters were measured. No significant changes in Hi levels in particular brain areas were found when compared to controls. Decreased activity of HD was found in hypothalamus (p less than 0.02). Increased activity of the enzyme was observed in "rest of brain", which consisted mainly of thalamus and striatum (p less than 0.05).