Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
Jae-Min Kim1, Hee-Ju Kang1, Ju-Wan Kim1
1Department of Psychiatry, Chonnam National University Medical School, Gwangju, Korea.
Objective:
We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS).
Methods:
Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates.
Results:
Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group.
Conclusion:
By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.
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