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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Updated: Aug 1, 2025

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
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Tendon Aging.

Ana Luísa Graça1,2, Manuel Gomez-Florit3, Manuela Estima Gomes1,2

  • 13B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal.

Sub-Cellular Biochemistry
|April 29, 2023
PubMed
Summary
This summary is machine-generated.

Aging tendons show decreased function and increased injury risk due to cellular and molecular changes. Understanding these age-related tendon alterations is crucial for developing targeted therapies for the elderly.

Keywords:
AgingBiomarkersImmune systemTendinopathyTendon cellsTendon tissue

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Area of Science:

  • Biomedical Engineering
  • Connective Tissue Biology
  • Gerontology

Background:

  • Tendons are vital mechanosensitive tissues enabling bodily movement.
  • Aging leads to tendon degeneration, increasing injury susceptibility and incapacity.
  • Current knowledge gaps exist in tendon biology, biomechanics, and disease mechanisms.

Purpose of the Study:

  • To elucidate the effects of aging on tendon tissue, cellular, and molecular levels.
  • To review potential biological predictors of tendon aging.
  • To inform the development of precision therapies for age-related tendon conditions.

Main Methods:

  • Review of recent research findings on tendon aging.
  • Analysis of tissue, cellular, and molecular changes in aging tendons.
  • Identification of biological predictors for tendon aging.

Main Results:

  • Aging significantly impacts tendon composition, structure, and biomechanical properties.
  • A decline in the regenerative potential of aged tendons is observed.
  • Specific biological changes associated with tendon aging have been identified.

Conclusions:

  • Aging profoundly affects tendon health and function, necessitating further research.
  • Understanding tendon aging mechanisms can guide the development of novel therapeutic strategies.
  • Precision therapies targeting the elderly population may improve tendon health outcomes.