Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

92
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
92
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

167
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
167
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Erikson's Theory on Socioemotional Development during Adulthood01:27

Erikson's Theory on Socioemotional Development during Adulthood

172
Erik Erikson's theory of psychosocial development outlines a series of stages through which individuals progress across the lifespan. Each stage involves a psychosocial conflict that significantly influences personal growth and well-being. Three key stages — intimacy versus isolation, generativity versus stagnation, and integrity versus despair — highlight the developmental challenges faced in adulthood.
Intimacy Versus Isolation in Early Adulthood
Individuals in early...
172
Menopause01:28

Menopause

213
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
213

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular senescence in ischemic stroke: Cell-type specificity, temporal dynamics, and response to therapeutic interventions.

Ageing research reviews·2026
Same author

The need to increase support for healthy ageing and longevity research in the EU by establishing a Coordination and Support Programme on Healthy Ageing and Longevity.

Mechanisms of ageing and development·2026
Same author

A Pilot Study of a Cognitive-Behavioral and Meaning-Centered Intervention to Mitigate Doping-Related Distress.

Current health sciences journal·2026
Same author

Chronobiological disruption in ADHD: Developmental mechanisms linking sleep, behavior, and comorbid conditions.

Progress in neuro-psychopharmacology & biological psychiatry·2026
Same author

Alginate gel embedding preserves antigenicity in free-floating brain sections.

Histology and histopathology·2026
Same author

Targeting the Biology of Aging in Cerebrovascular Disease: Inflammation, Metabolism, Senescence, and Regeneration.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Aug 1, 2025

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing
04:30

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing

Published on: October 25, 2019

5.7K

Clinical Ageing.

Roxana Surugiu1,2, Daiana Burdusel1,2, Mihai-Andrei Ruscu1

  • 1Experimental Research Centre for Normal and Pathological Aging, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Sub-Cellular Biochemistry
|April 29, 2023
PubMed
Summary
This summary is machine-generated.

Aging leads to declining health and increased disease risk. Regenerative medicine aims to restore function, but challenges remain, especially for stroke patients, highlighting the need for better diagnostics and prevention.

Keywords:
AgeingComorbiditiesDementiaGenomicsObesityRehabilitationStroke

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K
Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

3.4K

Related Experiment Videos

Last Updated: Aug 1, 2025

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing
04:30

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing

Published on: October 25, 2019

5.7K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K
Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

3.4K

Area of Science:

  • Gerontology and Regenerative Medicine
  • Neuroscience and Stroke Research

Background:

  • Aging is characterized by declining stress response, homeostatic imbalance, and increased disease risk due to accumulated molecular and cellular damage.
  • The aging population presents significant healthcare challenges due to age-associated diseases and impairments.
  • Regenerative medicine seeks to restore tissues lost to aging, disease, or injury, addressing the decline in natural regenerative capacity.

Purpose of the Study:

  • To discuss organ failure and hypothalamic-pituitary-adrenal axis aging, including regulatory drugs.
  • To explore the complexities of aging and regeneration, particularly concerning stem cell function in aged environments.
  • To review neurorestorative therapies for stroke in the elderly, considering challenges in cell-based treatments and the need for improved diagnostics.

Main Methods:

  • Review of current literature on aging, organ failure, and the hypothalamic-pituitary-adrenal axis.
  • Discussion of stem cell aging and the tissue environment's role in regeneration.
  • Analysis of challenges and recent advancements in cell-based therapies for ischemic stroke and biomarker discovery.

Main Results:

  • Aging impairs tissue regeneration, with stem cell function potentially affected by the aged microenvironment.
  • Cell-based therapies for stroke face significant hurdles in cell survival, migration, differentiation, and integration in the aged brain.
  • Neurovascular unit-derived exosomes show promise as novel biomarkers for ischemic stroke diagnosis.

Conclusions:

  • Understanding the fundamental mechanisms of aging and regeneration is crucial for developing effective therapies.
  • The safety and efficacy of cell therapy for stroke in elderly patients remain unproven due to integration challenges.
  • Investment in stroke prevention and the development of reliable biomarkers like exosomes are vital for managing age-related neurological conditions.