Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gallbladder function in diabetic patients.

D P Shreiner, R P Sarva, D Van Thiel

    Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    WHICH LIVER-DESEASE PATIENTS NEED A TRANSPLANT?: Organ replacement has come into its own as a treatment for end-stage liver disease. A team of experts from two leading transplant centers reviews current indications, survival rates, and methods of evaluating candidates for operation.

    Hospital record study : a joint study by CPHA and IMS America Ltd·2011
    Same author

    Association of HLA Compatibility and Decreased Liver Transplant Survival.

    Transplantation proceedings·2010
    Same author

    Effect of Cyclosporin-A on Hepatic and Renal Allograft Mononuclear Cell Infiltration.

    Transplantation proceedings·2010
    Same author

    A consensus conference on complex biologics and low molecular weight heparins.

    International angiology : a journal of the International Union of Angiology·2010
    Same author

    ALEX (artificial liver for extracorporeal xenoassistance): a new bioreactor containing a porcine autologous biomatrix as hepatocyte support. Preliminary results in an ex vivo experimental model.

    The International journal of artificial organs·2002
    Same author

    Hepatitis C and renal disease.

    Transplantation proceedings·2002
    Same journal

    Overall Survival with [<sup>177</sup>Lu]Lu-PSMA-617 Versus [<sup>177</sup>Lu]Lu-PSMA I&T: A Propensity Score-Matched Real-World Analysis.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    Toward a Biopsy-Free Diagnosis of Prostate Cancer: Potential of Combined <sup>18</sup>F-Flotufolastat PSMA PET and mpMRI.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    PSMA PET/CT-Targeted Biopsy in Men with Negative or Equivocal Multiparametric MRI and Exploratory Dynamic Total-Body PET: The FUPERMAN Study.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    Erratum.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    Live from 2026 SNMMI Annual Meeting in Los Angeles!

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    Same journal

    CAR T-Cell Therapy for Cancer: Updates and Challenges for Response Assessment.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
    See all related articles

    Diabetic patients, especially obese ones, show impaired gallbladder emptying, even without gallstones. This dysfunction, coupled with faster filling, may increase gallstone risk in this population.

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Nuclear Medicine

    Background:

    • Gallbladder function is crucial for digestion.
    • Diabetes mellitus can affect various bodily systems, including gastrointestinal motility.
    • Gallstone formation is a common complication, but its relationship with gallbladder dysfunction in diabetes is not fully understood.

    Purpose of the Study:

    • To investigate gallbladder filling and emptying dynamics in diabetic patients compared to healthy controls.
    • To assess the impact of obesity on gallbladder function in diabetic individuals.
    • To explore potential mechanisms predisposing diabetics to gallstones.

    Main Methods:

    • Utilized cholescintigraphy with [99mTc]disofenin for gallbladder imaging.
    • Administered octapeptide of cholecystokinin (OP-CCK) via intravenous infusion to stimulate gallbladder emptying.

    Related Experiment Videos

  • Compared gallbladder filling rates and emptying percentages between diabetic and control groups, and further analyzed subgroups of obese and nonobese diabetics.

    • Main Results:

    • Diabetic subjects exhibited a greater peak gallbladder filling rate than normal controls.
    • Gallbladder emptying in response to OP-CCK was significantly reduced in diabetic subjects (51.6%) compared to controls (77.2%).
    • Obese diabetics demonstrated substantially lower gallbladder emptying (30.0%) compared to nonobese diabetics (73.1%).

    Conclusions:

    • Obese diabetics may experience impaired gallbladder emptying, independent of gallstones.
    • Accelerated gallbladder filling in obesity suggests potential gallbladder hypotonicity.
    • The combination of impaired emptying and altered filling may increase the risk of gallstone development in obese diabetics.