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Antithrombotic treatment strategies in patients with established coronary atherosclerotic disease
Marco Valgimigli1,2, Victor Aboyans3, Dominick Angiolillo4
1Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Via Tesserete 48, 6900 Lugano, Switzerland.
Insights
This consensus updates antithrombotic strategies for coronary artery disease (CAD). It classifies treatments based on drug number to guide optimal patient selection for antithrombotic therapy.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Established guidelines exist for antithrombotic strategies in coronary artery disease (CAD).
- Evolving evidence and terminology necessitate updated clinical guidance.
Conclusions:
- The document offers a framework for selecting antithrombotic therapy in established CAD.
- Updated recommendations aim to optimize treatment selection for individual patients based on current evidence.
Abstract:
Multiple guidelines and consensus papers have addressed the role of antithrombotic strategies in patients with established coronary artery disease (CAD). Since evidence and terminology continue to evolve, the authors undertook a consensus initiative to guide clinicians to select the optimal antithrombotic regimen for each patient. The aim of this document is to provide an update for clinicians on best antithrombotic strategies in patients with established CAD, classifying each treatment option in relation to the number of antithrombotic drugs irrespective of whether the traditional mechanism of action is expected to mainly inhibit platelets or coagulation cascade. With the aim to reach comprehensiveness of available evidence, we systematically reviewed and performed meta-analyses by means of both direct and indirect comparisons to inform the present consensus document.
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