Related Experiment Video

Updated: Aug 1, 2025

In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines
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In Vitro Cultivation Techniques for Modeling Liver Organogenesis, Building Assembloids, and Designing Synthetic Tissues using Human Cell Lines

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ACLY-β-catenin axis modulates hepatoblastoma cell proliferation

Yanyan Lin1, Houshun Fang1, Chunshuang Ma1

  • 1Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Biochemical and Biophysical Research Communications
|April 30, 2023
PubMed
Summary

ATP citrate lyase (ACLY) promotes hepatoblastoma cell proliferation and survival by activating the Wnt/β-catenin pathway. Inhibiting ACLY offers a potential therapeutic strategy for treating this pediatric liver cancer.

Keywords:
ATP citrate LyaseHepatoblastomaLipometabolismTargeted therapyβ-catenin

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