Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.2K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.2K
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.7K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.7K
Stem Cell Culture01:17

Stem Cell Culture

5.3K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.3K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

5.3K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.3K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution: Neuronal impact on patterning in a regenerating sea anemone.

Current biology : CB·2026
Same author

The dynamic genomes of Hydra and the anciently active repeat complement of animal chromosomes.

Genome biology·2025
Same author

Hunger and satiety: Neuronal dynamics in Hydra behavior.

Cell reports·2024
Same author

The significance of Ethel Browne's research on Hydra for the organizer concept.

Cells & development·2024
Same author

A new look at the architecture and dynamics of the <i>Hydra</i> nerve net.

eLife·2024
Same author

The origin and evolution of Wnt signalling.

Nature reviews. Genetics·2024
Same journal

Estetrol potentiates progesterone-driven growth restraint while blunting pro-angiogenic activation in murine endometriosis lesions.

Cells & development·2026
Same journal

Transcriptomic signatures and neural cell composition in schizophrenia iPSC-derived neuron cultures.

Cells & development·2026
Same journal

Upregulation of adenylyl cyclase 1 is crucial for osteogenic and adipogenic differentiation of MSCs.

Cells & development·2026
Same journal

Toll-like receptors in epithelial mechanics and surveillance.

Cells & development·2026
Same journal

Functions and mechanisms of BRCA1 in early embryonic development.

Cells & development·2026
Same journal

The face you're born with: How early development dictates a lifetime of expression and ageing.

Cells & development·2026
See all related articles

Related Experiment Video

Updated: Aug 1, 2025

Generation of Transgenic Hydra by Embryo Microinjection
09:10

Generation of Transgenic Hydra by Embryo Microinjection

Published on: September 11, 2014

14.2K

The Hydra stem cell system - Revisited.

Thomas W Holstein1

  • 1Heidelberg University, Centre for Organismal Studies (COS), Molecular Evolution and Genomics, Im Neuenheimer Feld 230, D-69120 Heidelberg, Germany.

Cells & Development
|April 30, 2023
PubMed
Summary
This summary is machine-generated.

Hydra, a simple animal model, reveals complex stem cell biology akin to Bilateria. Its four stem cell lineages offer insights into aging, regeneration, and animal evolution.

Keywords:
Epithelial stem cellsGerm lineHomeostasisInjuryInterstitial stem cellsNematocytesNeuronal plasticityRegenerationWnt

More Related Videos

Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

12.6K
Fluorescent In Situ Hybridization and 5-Ethynyl-2'-Deoxyuridine Labeling for Stem-Like Cells in the Hydrozoan Jellyfish Cladonema pacificum
08:44

Fluorescent In Situ Hybridization and 5-Ethynyl-2'-Deoxyuridine Labeling for Stem-Like Cells in the Hydrozoan Jellyfish Cladonema pacificum

Published on: August 3, 2022

3.2K

Related Experiment Videos

Last Updated: Aug 1, 2025

Generation of Transgenic Hydra by Embryo Microinjection
09:10

Generation of Transgenic Hydra by Embryo Microinjection

Published on: September 11, 2014

14.2K
Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

12.6K
Fluorescent In Situ Hybridization and 5-Ethynyl-2'-Deoxyuridine Labeling for Stem-Like Cells in the Hydrozoan Jellyfish Cladonema pacificum
08:44

Fluorescent In Situ Hybridization and 5-Ethynyl-2'-Deoxyuridine Labeling for Stem-Like Cells in the Hydrozoan Jellyfish Cladonema pacificum

Published on: August 3, 2022

3.2K

Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Genomics

Background:

  • Cnidarians, ancient sister group to Bilateria, possess a complete metazoan genomic toolkit.
  • Hydra is a key model organism for aging, regeneration, and stem cell research.

Approach:

  • Leveraging single-cell RNA (scRNA) research for precise cell-type expression profiling.
  • Analyzing genomic data from major cnidarian clades (Aurelia, Clytia, Nematostella, Acropora).

Key Points:

  • Detailed characterization of Hydra's four stem cell lineages: epithelial (ectoderm, endoderm), multipotent somatic interstitial lineage (MPSC), and germline stem cell lineage (GSC).
  • Functional studies are refining understanding of stem cell homeostasis and properties in Hydra.
  • New data highlight Hydra's nervous system dynamics and plasticity, challenging plant system comparisons.

Conclusions:

  • Hydra's simple body plan serves as a prototype for animal stem cell lineages, mirroring Bilaterian properties.
  • Insights from Hydra's stem cell biology, germline, and regeneration are crucial for understanding metazoan development and evolution.