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Related Experiment Video

Updated: Aug 1, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

[RANKL and periodontitis].

Yutaro Ando^1,2, Masayuki Tsukasaki¹

¹Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

|April 30, 2023

Summary

Periodontal disease causes bone loss by activating the receptor activator of NF-κB ligand (RANKL). Understanding RANKL

Area of Science:

Oral biology
Immunology
Bone metabolism

Context:

Periodontal disease is a common infection leading to tooth loss.
Inflammation of periodontal tissues results in alveolar bone destruction.
Osteoimmunology plays a critical role in periodontal pathogenesis.

Purpose:

To elucidate the molecular mechanisms of periodontal bone destruction.
To highlight the role of receptor activator of NF-κB ligand (RANKL) in this process.

Summary:

Periodontal disease involves inflammation and destruction of alveolar bone.
Receptor activator of NF-κB ligand (RANKL), produced by osteoblasts and fibroblasts, is key to bone loss.
Immune system activation drives RANKL induction during periodontal inflammation.

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Last Updated: Aug 1, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

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Impact:

Provides insights into the osteoimmune pathways of periodontal disease.
Focuses on RANKL as a critical mediator of periodontal bone destruction.
Informs potential therapeutic strategies targeting RANKL in periodontal treatment.