Interaction between the left ventricular ejection fraction and left ventricular strain and its relationship with

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Updated: Aug 1, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.0K

Hai-Yan Gui1, Shu-Wen Liu2, Dong-Fang Zhu3

  • 1MRI Room, Harbin No. 4 Hospital, Harbin 150026, Heilongjiang Province, China.

World Journal of Clinical Cases
|May 1, 2023
PubMed

Insights

Left ventricular ejection fraction (LVEF) is linked to left ventricular strain (LVS) and coronary stenosis. Lower LVEF and altered LVS indicate more severe coronary artery disease, as shown by MRI.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiac Physiology

Background:

  • Coronary artery stenosis (CAS) is a leading cause of death, characterized by plaque buildup narrowing heart arteries.
  • Reduced blood and oxygen supply to the heart muscle can lead to permanent damage, often due to blood clots.
  • Heart attacks are frequently caused by sudden blockages in coronary arteries.

Purpose of the Study:

  • To investigate the relationship between left ventricular ejection fraction (LVEF), left ventricular strain (LVS), and the severity of coronary stenosis.
  • To analyze how cardiac function, assessed by LVEF and LVS, correlates with coronary artery narrowing.

Main Methods:

  • 190 participants (97 with coronary heart disease, 93 healthy controls) were analyzed.
  • Left ventricular ejection fraction (LVEF) and left ventricular strain (LVS) were measured using magnetic resonance imaging (MRI).
  • Coronary lesion severity was quantified using the Gensini score; statistical analyses included linear regression and Spearman's correlation.

Main Results:

  • Patients with coronary artery disease showed lower LVEF and altered LVS compared to healthy controls.
  • Increased coronary stenosis severity (higher Gensini score) correlated with decreased LVEF and increased ventricular volumes (LVESV, LVEDV).
  • LVEF demonstrated a significant negative linear correlation with LVS and coronary stenosis severity.

Conclusions:

  • Left ventricular ejection fraction (LVEF), as measured by MRI, is a reliable indicator of left ventricular strain (LVS).
  • LVEF is significantly and negatively correlated with the severity of coronary stenosis.
  • These findings highlight the utility of LVEF and LVS in assessing cardiac function in patients with coronary artery disease.
Abstract

Keywords:
Coronary stenosisLeft ventricular ejection fractionLeft ventricular end-diastolic volumeLeft ventricular end-systolic volumeLeft ventricular strainMagnetic resonance imaging

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