Related Experiment Video

Updated: Aug 1, 2025

Intracranial Injection of Adeno-associated Viral Vectors
08:47

Intracranial Injection of Adeno-associated Viral Vectors

Published on: November 17, 2010

47.7K

Adverse events following COVID-19 immunisation (AEFI) at a COVID-19 vaccination centre: An observational analytical

Vinita Shukla1, Beena Sachan1, Sugandha Jauhari2

  • 1Department of Community Medicine, Dr. R.M.L.I.M.S, Lucknow, Uttar Pradesh, India.

Journal of Family Medicine and Primary Care
|May 1, 2023
PubMed

Insights

COVID-19 vaccines are safe, with most adverse events following immunisation (AEFI) being minor reactions. Higher AEFI incidence was observed in older age groups, but comorbidities showed no association with severity.

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) vaccination programs aim to reduce disease severity and transmission.
  • Understanding adverse events following immunisation (AEFI) across different demographics is crucial for vaccine safety monitoring and public confidence.

Purpose of the Study:

  • To determine the incidence and characteristics of AEFI in various age groups following COVID-19 vaccination.
  • To assess the association between comorbidities and the occurrence or severity of AEFI.

Main Methods:

  • An observational analytical study was conducted on 1002 participants who received two doses of a COVID-19 vaccine.
  • Participants were categorized into three age groups: 18-44 years, 45-60 years, and over 60 years.
  • Data on AEFI were collected via semi-structured questionnaires during home visits.

Main Results:

  • The incidence of any AEFI was highest in the >60 years age group (31.9%), followed by 45-60 years (19.74%), and 18-44 years (15.17%).
  • AEFI severity was greater in the 18-44 years group (66.1%) compared to the 45-60 years (30.67%) and >60 years groups.
  • Fever and injection site pain/inflammation were the most frequently reported AEFI. No association was found between comorbidities and AEFI severity.

Conclusions:

  • COVID-19 vaccines demonstrate a favorable safety profile, with predominantly minor and expected immunogenic reactions.
  • The observed AEFI rates and types are consistent with general vaccine responses.
  • High vaccine uptake across all recommended age groups is encouraged to mitigate the impact of COVID-19.
Abstract

Keywords:
Adverse events following immunisationCOVID-19COVID-19 vaccineimmunisationvaccination

More Related Videos

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-1908:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.0K
Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development09:03

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

8.7K

Related Concept Videos

Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
923
Vaccinations01:51

Vaccinations

Overview
44.9K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
465
Types of Reports II: Incident or Occurrence Report01:21

Types of Reports II: Incident or Occurrence Report

An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
901
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.1K
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
904