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Updated: Aug 1, 2025
Remote Laboratory Management: Respiratory Virus Diagnostics
Published on: April 6, 2019
Molecular and Physiological Study in Patients with Coronavirus in Thi-Qar Province Iraq
M Obaid Khazaal1, M Çanlı2, E Abdul Kareem Jabbar3
1Ahi Evran University, Kırşehir, Turkey.
Insights
This study found that COVID-19 significantly alters physiological parameters, including decreased hemoglobin and platelets, and increased white blood cells (WBC). These COVID-19 effects varied by gender, impacting blood urea and sugar levels differently.
Area of Science:
- Medical Science
- Infectious Diseases
- Physiology
Background:
- COVID-19 is a global pandemic with diverse clinical manifestations.
- Understanding the physiological impact of COVID-19 is crucial for patient management.
- Previous research indicates potential hematological and biochemical alterations in COVID-19 patients.
Purpose of the Study:
- To investigate the effects of COVID-19 on key physiological parameters.
- To assess differences in these parameters based on patient gender and age.
- To analyze specific biomarkers such as C-reactive protein (CRP), ferritin, and D-dimer.
Main Methods:
- A cohort of 100 COVID-19 patients and 50 controls were studied.
- Hematological parameters (hemoglobin, WBC, platelets, lymphocytes) were analyzed.
- Biochemical markers (blood urea, creatinine, random blood sugar) and inflammatory markers (CRP, ferritin, D-dimer) were measured.
- Sequencing analysis was performed on isolated viral samples.
Main Results:
- COVID-19 patients showed significantly lower hemoglobin, lymphocytes, and platelets, but higher white blood cells (WBC) compared to controls.
- Males exhibited higher hemoglobin, WBC, and platelets, while females had higher lymphocytes.
- Elevated blood urea, serum creatinine, and random blood sugar were observed in patients. Blood urea was higher in females, and blood sugar in males. Older patients (>70 years) had higher blood urea.
- CRP, ferritin, and D-dimer levels were significantly elevated in patients, with higher D-dimer in females and higher CRP in the youngest age group.
Conclusions:
- COVID-19 significantly impacts hematological and biochemical profiles.
- Gender-specific physiological responses to COVID-19 were observed.
- Elevated inflammatory markers suggest a systemic inflammatory response in COVID-19 patients.
Abstract:
The current study aimed to study the effect of Covid-19 disease on some physiological parameters for assessing the physiological effect of Covid-19. The current study included 100 patients, 50 males, and 50 females, whose ages ranged from 10 - 73 years infected with Covid-19 molecularly diagnosed at AL-Imam Hussein Teaching Hospital in Thi-Qar Province from April to August 2021 and 50 people as a control group. The results illustrated a significant decrease in the level of hemoglobin, lymphocyte, and platelet in the patient's group, whereas a significant increase in the count of total white blood cells (WBC) was recorded in patients compared with the control group. The results showed that the hemoglobin level, WBC, and platelet increased significantly in males compared to females, while the lymphocytes increased significantly in female patients. The results of age groups showed non-significant differences in the hematological parameters. The current results illustrated a significant increase in the level of blood urea, serum creatinine, and random blood sugar in the patient's group. According to the gender of patients, the blood urea increased significantly in the female group, while the blood sugar increased significantly in the male group. On the other hand, the serum creatinine had no significant difference. According to age groups, a significant increase in blood urea was recorded in patients over 70 years, but no differences in both creatinine and random blood sugar level were noted. The current study recorded that the concentration of CRP, ferritin, and D. Dimer was significantly higher in patients; according to gender, the level of CRP and ferritin increased non-significantly compared with a male group of patients, while D. Dimer increased significantly in the female group. According to age group, only CRP increased significantly in the first age group compared with other age groups. The sequencing analysis was performed for 10 isolated Covid-19, and the result indicates that only one isolated sample has a sequencing identity of 99,5% with Covid-19 in Iran.
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