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SMARCA4-deficient undifferentiated thoracic tumor: A case report
1Department of Pathology, Yeungnam University Medical Center, Daegu 42415, South Korea.
World Journal of Clinical Cases
|May 1, 2023
Summary
SMARCA4-deficient undifferentiated tumors (SMARCA4-DUTs) are aggressive thoracic malignancies. Diagnosis relies on clinical presentation, lack of epithelial differentiation, and confirmed loss of SMARCA4 expression via immunohistochemistry.
Area of Science:
- Oncology
- Pathology
- Thoracic Surgery
Background:
- SMARCA4-deficient undifferentiated tumors (SMARCA4-DUTs) are aggressive, rapidly progressing malignancies.
- These tumors affect middle-aged individuals and are linked to smoking history.
- Distinguishing SMARCA4-DUTs from other cancers poses a diagnostic challenge.
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