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Published on: February 28, 2025
Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound
A A P Mansur1, M A Rodrigues2, N S V Capanema1
1Department of Metallurgical and Materials Engineering, Center of Nanoscience, Nanotechnology and Innovation - CeNano2I, Federal University of Minas Gerais Av. Antônio Carlos 6627 - Escola de Engenharia, Bloco 2 - Sala 2233, 31.270-901 Belo Horizonte MG Brazil hmansur@demet.ufmg.br +55-31-34091843.
Abstract:
Wounds produced by trauma, burns, and chronic diseases cause millions of patients to suffer discomfort, pain, and, in many cases, disability and death, leading to enormous health, social and financial impacts globally. Regrettably, current clinical treatments for chronic wounds remain unsatisfactory. Thus, this study reports for the first time the design, development, and synthesis of chemically biofunctionalized hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked by citric acid using an entirely biocompatible and green process. They demonstrated suitable physicochemical properties, cytocompatibility, and hemocompatibility to be applied as a smart wound dressing for skin tissue engineering. These novel hybrids were biofunctionalized with l-arginine and RGD peptide through carbodiimide mediated-amide formation to promote bioadhesion of fibroblast and keratinocyte cells as a potential enhancement for wound healing and skin tissue engineering applications.
