Related Experiment Video
Updated: Aug 1, 2025
06:28
A Simple Flow Cytometric Method to Measure Glucose Uptake and Glucose Transporter Expression for Monocyte Subpopulations in Whole Blood
Published on: August 12, 2016
16.7K
Abnormal glucose metabolism in virus associated sepsis
Peng Zhang1, Shangwen Pan1, Shiying Yuan1
1Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in Cellular and Infection Microbiology
|May 1, 2023
Summary
Viral sepsis, a severe condition, involves cellular metabolic changes impacting host response. This study investigates glucose metabolism alterations during viral sepsis to identify new therapeutic targets.
Area of Science:
- Virology
- Immunology
- Metabolic Medicine
Background:
- Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection.
- Viral sepsis, specifically, results from the host's inappropriate reaction to viral infections.
- Cellular metabolic alterations during viral infections are known to influence host response, but remain poorly understood.
Purpose of the Study:
- To investigate the specific changes in glucose metabolism during viral sepsis.
- To understand how these metabolic alterations impact viral infection progression.
- To identify potential novel therapeutic targets for managing viral sepsis.
Main Methods:
- Focus on alterations in glucose metabolism pathways during viral sepsis.
- Analysis of the interplay between cellular metabolism and viral infection dynamics.
- Exploration of potential therapeutic interventions targeting metabolic pathways.
Main Results:
- Detailed characterization of glucose metabolism dysregulation in viral sepsis.
- Demonstration of how metabolic shifts influence viral replication and host immunity.
- Identification of key metabolic nodes as potential therapeutic targets.
Conclusions:
- Cellular glucose metabolism is significantly altered during viral sepsis.
- Targeting metabolic pathways presents a promising strategy for novel viral sepsis therapies.
- Further research into metabolic reprogramming in viral infections is warranted.
Related Concept Videos
01:19Overview of Carbohydrate Metabolism
1.3K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.3K
01:27Glucose Transporters
23.8K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
23.8K
01:15Hypoglycemia and Glucagon
306
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
306
01:20Pathophysiology of Diabetes
1.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.0K
01:27Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
1.3K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
Insulin and C-peptide are...
1.3K
01:02Glucose Homeostasis: Regulation of Blood Glucose
1.8K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.8K